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| Catalog Code: | NB110-74983 |
| Product Name: | TRPC3 Antibody |
| Product Description: | Sheep Polyclonal anti-TRPC3 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | TRPC3_RAT |
| Immunogen: | A synthetic peptide as a part of rat short transient receptor potential channel 3 (TRPC3) conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for TRPC3. |
| Cross Reactivity: | Rat. Other species not yet tested. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Background: | FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable). |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Sheep |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:300 to 1:4000 |
| Species Summary: | Rt. |
| Alternate Names: | anti-Short transient receptor potential channel 3 antibody, anti-transient receptor potential cation channel antibody, anti-subfamily C antibody, anti-member 3 antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Ohki G, et al. J. Biol. Chem. 275:39055-39060(2000). 2. Onohara,N, et al. EMBO J. 25 (22), 5305-5316 (2006). 3. Bush,E.W, et al. J. Biol. Chem. 281 (44), 33487-33496 (2006). 4. Liu,D, et al. Am. J. Hypertens. 18 (11), 1503-1507 (2005). 5. Thebault,S, et al. J. Cell. Physiol. 204 (1), 320-328 (2005). 6. Yildirim,E, et al. Proc. Natl. Acad. Sci. U.S.A. 102 (9), 3307-3311 (2005). 7. Wu,X, et al. J. Biol. Chem. 279 (42), 43392-43402 (2004). 8. Singh,B.B, et al. Mol. Cell 15 (4), 635-646 (2004). 9. Santillan,G, et al. J. Steroid Biochem. Mol. Biol. 89-90 (1-5), 291-295 (2004). 10. Baldi,C, et al. J. Cell. Biochem. 90 (1), 197-205 (2003) |
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