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| Catalog Code: | NB110-74742 |
| Product Name: | SCNN1D Antibody |
| Product Description: | Rabbit Polyclonal anti-SCNN1D |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | SCNED_HUMAN |
| Immunogen: | A synthetic peptide as a part of human amiloride-sensitive sodium channel subunit delta (SCNED, SCNN1D) conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for SCNN1D. |
| Cross Reactivity: | Human. Other species not yet tested. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Localization: | Membrane; multi-pass membrane protein |
| Background: | FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.; SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry , Western Blot 1:300 to 1:4000 |
| Species Summary: | Hu |
| Alternate Names: | anti-Epithelial Na(+) channel subunit delta antibody, anti-delta-ENaC antibody, anti-nonvoltage-gated sodium channel 1 subunit delta antibody, anti-SCNED antibody, anti-delta-NaCH antibody, anti-dNaCh antibody, anti-ENaCdelta antibody, anti-MGC149710 antibody, anti-MGC149711 antibody, anti-DNACH antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Waldmann R, et al. J. Biol. Chem. 270:27411-27414(1995). 2. Ota T, et al. Nat. Genet. 36:40-45(2004). 3. Gregory S.G, et al. Nature 441:315-321(2006). 4. Giraldez,T, et al. J. Neurochem. 102 (4), 1304-1315 (2007). 5. Yamamura,H, et al. Biochem. Biophys. Res. Commun. 349 (1), 317-321 (2006). 6. Ji,H.L, et al. J. Biol. Chem. 281 (12), 8233-8241 (2006). 7. Ji,H.L, et al. J. Biol. Chem. 279 (26), 26939-26947 (2004). |
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