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| Catalog Code: | NB110-74736 |
| Product Name: | HCN4 Antibody |
| Product Description: | Rabbit Polyclonal anti-HCN4 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | HCN4_RAT ; HCN4_MOUSE |
| Immunogen: | A synthetic peptide as a part of rat and mouse potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for HCN4. |
| Cross Reactivity: | Rat and mouse. Other species not yet tested. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Localization: | Membrane; multi pass membrane protein. |
| Background: | FUNCTION: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli.; SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Highly expressed in pyramidal and granule layer of the hippocampus, in thalamus anterior nucleus, in the supraoptic nucleus in hypothalamus, in cerebellum, and in trapezoid nuclei and superior olivary complex in the auditory system. Detected in a subset of elongated cells in taste buds. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry, Western Blot 1:300 |
| Species Summary: | Rt, Mu |
| Alternate Names: | anti-HCN 4 antibody, anti-Hyperpolarization activated cyclic nucleotide gated potassium channel 4 antibody, anti-Potassium sodium hyperpolarization activated cyclic nucleotide gated channel 4 antibody, anti-Potassium/sodium hyperpolarization activated cyclic nucleotide gated channel 4 antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Monteggia L.M, et al. Brain Res. Mol. Brain Res. 81:129-139(2000). 2. Shi W, et al. Circ. Res. 85:1-6(1999). 3. Stevens D.R, et al. Nature 413:631-635(2001). |
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