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| Catalog Code: | NB110-74721 |
| Product Name: | OPN3 Antibody |
| Product Description: | Rabbit Polyclonal anti-OPN3 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Omim ID: | OPN3_HUMAN |
| Immunogen: | A synthetic peptide as a part of human opsin-3 (OPN3, ECPN, encephalopsin, panopsin) conjugated to immunogenic carrier protein was used as the immunogen. |
| Specificity: | Appears to be specific for opsin-3. |
| Cross Reactivity: | Human. Other species not yet tested. |
| Packaging: | 0.1 ml of Whole antisera antibody |
| Uses: | IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. |
| Localization: | Membrane; Multi-pass membrane protein. |
| Background: | Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. FUNCTION: May play a role in encephalic photoreception. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Buffer: | Lyophilised in PBS |
| Application Summary: | immunohistochemistry, Western Blot 1:300 |
| Species Summary: | Hu |
| Alternate Names: | anti-ECPN antibody, anti-ERO antibody, anti-NMO 1 antibody, anti-NMO1 antibody, anti-OPN 3 antibody, anti-OPN3 antibody, anti-Opsin 3 antibody, anti-Opsin3 antibody, anti-Panopsin antibody |
| Package Size: | 0.1 ml |
| Preservative: | No Preservative |
| Notes Main: | Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| General References: | 1. Blackshaw S, et al. J. Neurosci. 19:3681-3690(1999). 2. Halford S, et al. Genomics 72:203-208(2001). 3. Kasper G, et al. Gene 295:27-32(2002). 4. Gregory S.G, et al. Nature 441:315-321(2006). 5. Alam N.A, et al. Cancer Genet. Cytogenet. 147 (2), 121-127 (2003). |
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