| Catalog Code: | NB110-7203 |
| Product Type: | Primary Antibody |
| Product Name: | Parkin Antibody |
| List Price: | 295 |
| Clonality: | Polyclonal |
| Gene ID: | 5071 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-Parkin |
| Cross Reactivity: | Cross-reacts with Human and Rat. Not yet tested in other species. |
| Species Summary: | Hu, Rt |
| Background: | Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ub |
| Alternate Names: | anti-Ubiquitin E3 ligase PRKN antibody, anti-Parkinson juvenile disease protein 2 antibody, anti-Parkinson disease protein 2. GENE NAME: PARK2 antibody, anti-PRKN antibody |
| Immunogen: | Synthetic peptide: IKELHHFRILGEEQYN, corresponding to amino acids 298-313 of Human Parkin. This sequence is completely conserved between human, mouse and rat. |
| Purity: | Immunogen affinity purified |
| Buffer: | Constituents: PBS, 1mg/ml BSA |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Package Size: | 0.1 mg |
| Concentration: | 1 mg/ml |
| Uses: | IHC-Fr: Use at a concentration of 1 ug/ml. WB: Use at a concentration of 0.5 ug/ml. Detects a band of approximately 52 kDa representing recombinant human parkin. |
| Application Summary: | IHC-Fr, WB |
| General References: | General / background references:Fallon L et al. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem 277:486-91 (2002). Tanaka K et al. Parkin |