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| Catalog Code: | NB110-66722 |
| Product Name: | Urokinase Antibody |
| Product Description: | Sheep Polyclonal anti-Urokinase |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Native human uPA. |
| Specificity: | Recognizes human uPA alone and also as a complex under reducing and native conditions. |
| Packaging: | 0.1 mg protein G purified Sheep antisera. |
| Background: | Urokinase is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor. |
| Storage: | Store at -80 degrees C long term. |
| Purity: | protein G purified |
| Host Name: | Sheep |
| Buffer: | 0.05M Sodium Phosphate, pH 6.6 containing 0.1M Sodium Chloride and 1mM EDTA |
| Application Summary: | ELISA 1/100,000, Western Blot 1-5 ug/ml |
| Alternate Names: | anti-ATF antibody, anti-ATF uPA antibody, anti-Plasminogen activator antibody, anti-Plasminogen activator urinary antibody, anti-Plasminogen activator urokinase antibody, anti-PLAU antibody, anti-u PA antibody, anti-U plasminogen activator antibody, anti-UPA antibody, anti-URK antibody, anti-Urokinase plasminogen activator antibody, anti-Urokinase type plasminogen activator antibody, anti-Urokinase type plasminogen activator precursor antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservative |
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more information: | company product webpage |