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| Catalog Code: | NB110-66670 |
| Product Name: | PDGF Receptor Beta Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-PDGF Receptor Beta (EP2136Y) [Tyr857] |
| Clone: | EP2136Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Tyrosine 857 of human PDGF-Receptor β was used as an immunogen. |
| Specificity: | This antibody detects PDGF-Receptor β phosphorylated at Tyrosine 857. |
| Cross Reactivity: | This antibody is reactive against Mouse. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blot. |
| Background: | Human platelet-derived growth factor (PDGF) receptor, is a receptor tyrosine kinase whose activity induces various signalling cascades leading to cell growth and proliferation. Phosphorylation of Tyrosine 857 (pY857) in the catalytic loop of the PDGF Receptor beta has been shown to increase kinase activity. Two major isoforms exist, PDGF receptor-á and PDGF receptor-â. PDGF receptor-â can only bind two specific PDGF isoforms, PDGF-â and PDGF-Ä (1,2). Upon ligand binding, the receptor undergoes autophosphorylation, allowing binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules such as PI kinase (3), Grb2, and Src, among others. |
| Storage: | Aliquot and store at -20 °C. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot 1:500-1:1000, |
| Species Summary: | Mu, |
| Alternate Names: | Anti-Beta platelet derived growth factor receptor antibody, Anti-CD 140B antibody, Anti-CD140B antibody, Anti-CD140b antigen antibody, Anti-JTK12 antibody, Anti-PDGF R beta antibody, Anti-PDGFR antibody, Anti-PDGFR1 antibody, Anti-PDGFRB antibody, Anti-Platelet derived growth factor receptor beta antibody, Anti-Platelet derived growth factor receptor beta polypeptide antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| Phosphorylated: | Tyr857 |
| General References: | 1. Deuel, T.F., et al. Biofactors 1: 213-217 (1988). 2. Deuel, T.F., et al. J Clin Invest. 74: 669-76 (1984). 3. Kazlauskas, A, et al. Cell 58: 1121-33 (1989). |
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