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| Catalog Code: | NB110-66669 |
| Product Name: | PLC gamma II Antibody |
| Product Description: | Rabbit Monoclonal anti-PLC gamma II (EP1402Y) |
| Clone: | EP1402Y |
| Clonality: | Monoclonal |
| ListPrice: | 320 |
| Immunogen: | A synthetic peptide corresponding to residues near the C-terminus of human PLC gamma II was used as an immunogen. |
| Specificity: | This antibody is reactive to residues near the C-terminus of human PLC gamma II. |
| Cross Reactivity: | This antibody is reactive against Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blot. |
| Background: | Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. The phospholipase C gamma-2 (PLCãII) is an enzyme that plays a crucial role in intracellular signal transduction pathways. This enzyme is important because of its role in the generation of second messengers following the hydrolysis of phosphatidylinositol 4,5-bisphosphate (1). PLCãII has been implicated in collagen-induced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLCãII (2). It has also been shown that PLCãII was required for receptor activator of NF-kappaB ligand-induced (RANKL-induced) osteoclastogenesis by differentially regulating nuclear factor of activated T cells c1 (NFATc1), activator protein-1 (AP1), and NF-kappaB (3). |
| Storage: | Aliquot and store at -20 °C. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot 1:1000-1:2000, |
| Species Summary: | Hu, |
| Alternate Names: | Anti-1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody, Anti-EC 3.1.4.11 antibody, Anti-Phosphoinositide phospholipase C antibody, Anti-Phospholipase C gamma 2 antibody, Anti-PLC 2 antibody, Anti-PLC gamma 2 antibody, Anti-PLC IV antibody, Anti-PLCG2 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Argeson AC, et al. Genomics 25(1):29-35, 1995. 2. Ozdener F, et al. Mol Pharmacol 62(3):672-9, 2002. 3. Mao D, et al. J Clin Invest 166(11):2869-79, 2006. |
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