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| Catalog Code: | NB110-66667 |
| Product Name: | Presenilin-1 Antibody |
| Product Description: | Rabbit Monoclonal anti-Presenilin-1 (EP1998Y) |
| Clone: | EP1998Y |
| Clonality: | Monoclonal |
| ListPrice: | 315 |
| Immunogen: | A synthetic peptide corresponding to residues NTF subunit of Presenilin-1 protein was used as an immunogen. |
| Specificity: | This antibody reacts to residues NTF subunit of Presenilin-1 protein. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blot and FACS. |
| Background: | Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3). |
| Storage: | Aliquot and store at -20 °C. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | flow cytometry / FACS analysis 1:10, Western Blot 1:500-1:2000, |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | Anti-AD 3 antibody, Anti-AD3 antibody, Anti-Alzheimer Disease 3 antibody, Anti-FAD antibody, Anti-Homo Sapiens Clone CC44 Senilin 1 antibody, Anti-Presenilin1 antibody, Anti-Presenilin 1 antibody, Anti-Protein S182 antibody, Anti-PS 1 antibody, Anti-PS1 antibody, Anti-PSEN 1 antibody, Anti-PSEN1 antibody, Anti-PSNL 1 antibody, Anti-PSNL1 antibody, Anti-S182 antibody, Anti-S182 Protein antibody, Anti-Senilin 1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Steiner H, et al. J Biol Chem. 274(40):28669-73, 1999. 2. Kimberly WT, et al. J Biol Chem 275(5):3173-8, 2000. 3. Kopan et al. Gene Dev. 14(22):2799-2806, 2000. |
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