| CatalogCode: | NB110-66664 |
| ProductName: | p27 (Kip1) Antibody |
| Product Description: | Rabbit Monoclonal anti-p27 (Kip1) (EP233(2)Y) [Ser10] |
| Clone: | EP233(2)Y |
| Clonality: | Monoclonal |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Serine 10 of human p27 was used as an immunogen. |
| Specificity: | This antibody detects p27 phosphorylated at Serine 10. |
| CrossReactivity: | This antibody is reactive against Human, Mouse, and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blot, Immunohistochemistry, and Immunoprecipitation. |
| Control: | MCF-7 cell lysate, human ovarian carcinoma, Human tonsils |
| Background: | p27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27(Kip1) binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4 (1). p27(Kip1) is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27(Kip1) (2); while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 295 |
| AppSummary: | IHC, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | CDKN 1B antibody CDKN 4 antibody CDKN1B antibody CDKN4 antibody Cyclin Dependent Kinase Inhibitor 1B antibody Cyclin dependent kinase inhibitor p27 antibody KIP 1 antibody KIP1 antibody MEN1B antibody p27 Kip1 antibody P27KIP1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Polyak K., et al; Cell 78:59-66,1994. 2. Carrano,A.C., et al. Nat. Cell Biol., 1, 193-199 3. Rodier,G.,et al. EMBO J., 20, 6672-6682, 2001 |
| Phosphorylated: | Ser10 |
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