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| Catalog Code: | NB110-66660 |
| Product Name: | Erk1/p44 Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-Erk1/p44 (EP197Y) [Tyr202/Tyr204] |
| Clone: | EP197Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Threonine 202 and 204 of human Erk1/p44 was used as the immunogen. |
| Specificity: | This antibody detects Erk1/p44 phosphorylated at Threonine 202 and 204. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blot and Immunoprecipitation. |
| Background: | Extra cellular signal-regulated kinases Erk1 (p44 MAPK) Serine/Threonine protein kinase is part of a subfamily of mitogen-activated protein kinases that participate in diverse cellular functions, including the regulation of cell growth, differentiation, apoptosis and signal transduction (1,2,3). Erk1 regulates meiosis and mitosis by phosphorylating a number of transcription factors such as ELK-1. Activation of Erk1 occurs through phosphorylation of threonine 202 and tyrosine 204 (of human MAP kinase) . Erk1 is also known to autophosphorylate on tyrosine (4). |
| Storage: | Aliquot and store at -20 °C. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | immunoprecipitation 1:20, Western Blot 1:1000-1:2000, |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | Anti-ERK 1 antibody, Anti-ERK1 antibody, Anti-ERT 2 antibody, Anti-ERT2 antibody, Anti-Extracellular Signal Regulated Kinase 1 antibody, Anti-Extracellular signal related kinase 1 antibody, Anti-HGNC6877 antibody, Anti-HS44KDAP antibody, Anti-HUMKER1A antibody, Anti-Insulin Stimulated MAP2 Kinase antibody, Anti-MAP kinase 1 antibody, Anti-MAP Kinase antibody, Anti-MAPK 1 antibody, Anti-MAPK 3 antibody, Anti-MAPK1 antibody, Anti-MAPK3 antibody, Anti-MGC20180 antibody, Anti-Microtubule Associated Protein 2 Kinase antibody, Anti-Mitogen Activated Protein Kinase 3 antibody, Anti-p44 ERK1 antibody, Anti-p44 MAPK antibody, Anti-P44ERK1 antibody, Anti-P44MAPK antibody, Anti-PRKM 3 antibody, Anti-PRKM3 antibody, Anti-Protein Kinase Mitogen Activated 3 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| Phosphorylated: | Tyr202/Tyr204 |
| General References: | 1. Charest, D.L, et al. Mol Cell Biol. 13: 4679-90, 1993. 2. Marshall, C.J. Cell 80: 179-185, 1995 3. Brott, B. K. et al. Cell Growth Differ. 4, 921-9294, 1993 4. Payne, D.M., et al. EMBO J. 10: 885-892 1991. |
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