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| Catalog Code: | NB110-66659 |
| Product Name: | GSK3 Alpha/Beta Antibody |
| Product Description: | Rabbit Monoclonal anti-GSK3 Alpha/Beta (EP933Y) |
| Clone: | EP933Y |
| Clonality: | Monoclonal |
| ListPrice: | 320 |
| Immunogen: | A synthetic peptide corresponding to residues in human GSK3á/â was used as an immunogen. |
| Specificity: | This antibody detects both GSK á and GSK3â. |
| Cross Reactivity: | This antibody is reactive against Human, Mouse, and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blots. |
| Background: | Glycogen synthases kinase 3 alpha (GSK3-á) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-á activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-á by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-á activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4). GSK3 beta) plays a key role in insulin and Wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event (5). |
| Storage: | Aliquot and store at -20 °C. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot 1:1000-1:2000, |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | Anti-C86142 antibody, Anti-DKFZp686D0638 antibody, Anti-FA antibody, Anti-Factor A antibody, Anti-Glycogen Synthase Kinase 3 Alpha and Beta antibody, Anti-Glycogen synthase kinase 3 alpha antibody, Anti-Glycogen synthase kinase 3 beta antibody, Anti-GSK 3 alpha antibody, Anti-GSK 3 antibody, Anti-GSK 3 beta antibody, Anti-GSK 3A antibody, Anti-GSK 3B antibody, Anti-GSK3 alpha antibody, Anti-GSK3 beta antibody, Anti-Gsk3a antibody, Anti-GSK3B antibody, Anti-KG3A antibody, Anti-KG3B antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| General References: | 1. Martinho RG, et al. EMBO J. 17:7239-7249, 1998. 3. Sanchez Y, et al. Science 277:1497-1501, 1997 4. Lovestone S, et al. Curr Biol 4(12):1077-1086, 1994. 5. Dajani R, et al. Cell 105(6): 721-32 |
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