| CatalogCode: | NB110-66649 |
| ProductName: | SHP-2 Antibody |
| Product Description: | Rabbit Monoclonal anti-SHP-2 (EP508(2)Y) [Tyr542] |
| Clone: | EP508(2)Y |
| Clonality: | Monoclonal |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Tyrosine 542 of human SHP-2 was used as an immunogen. |
| Specificity: | This antibody detects SHP-2 phosphorylated at Tyrosine 542. |
| CrossReactivity: | This antibody is reactive against Human and Mouse. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blot, Immunocytochemistry, and Immunoprecipitation. |
| Control: | NIH/3T3 cell lysates |
| Background: | SHP-2 (also called PTP2C, SH-PTP2, PTP1D, SH-PTP3, Syp and PTPN11) is a protein tyrosine phosphatase (PTP) expressed in most cell types (unlike SHP-1), (1). SHP-2 is involved in the signal transduction stimulated by EGF, PDGF and Insulin. After cell stimulation, SHP-2 (as well as SHP-1), translocates from cytosol to the plasma membrane and binds to tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). When phosphorylated, SHP-2 has been shown to bind Grb2, EGFR, PDGFR, IRS-1 via its SH2 domain (3). Overexpression of SHP-2 leads to Juvenile Myelo-monocytic Leukemia and Noonan syndrome (4-5). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| ListPrice: | 295 |
| AppSummary: | IP, WB, ICC |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | Anti-BPTP 3 antibody; Anti-BPTP3 antibody; Anti-CFC antibody; Anti-MGC14433 antibody; Anti-Noonan syndrome 1 antibody; Anti-Noonan syndrome 1 protein tyrosine phosphatase 2C antibody; Anti-NS1 antibody; Anti-Protein tyrosine phosphatase 2C antibody; Anti-Protein Tyrosine Phosphatase Non receptor Type 11 antibody; Anti-SAP2 antibody; Anti-SH2 domain containing protein tyrosine phosphatase 2 antibody; Anti-SHIP2 antibody; Anti-SHP 2 antibody; Anti-SHP2 antibody; Anti-SHPTP 2 antibody; Anti-SHPTP2 antibody; Anti-SHPTP3 antibody; Anti-SIT protein precursor antibody; Anti-Syp antibody; Anti-Tyrosine protein phosphatase non receptor type 11 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Ahmad, et al: Proc. Nat. Acad. Sci. 90: 2197-2201, 1993 2. Klingmüller, U., Lorentz, U., Cantley, L. C., Neel, B. G., and Lodish, H. F. (1995) Cell 80, 729-738 3. Xiao et al (1994) J. Biol. Chem. 269, 21244-212484. 4. Tartaglia et al.Hum. Genet. 70: 1555-1563, 2002. 5. Tartaglia et al. Nature Genet. 34: 148-150, 2003. |
| Phosphorylated: | Tyr542 |
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