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| Catalog Code: | NB110-66648 |
| Product Name: | RSK-1 Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-RSK-1 (EP2133Y) [Thr573] |
| Clone: | EP2133Y |
| Clonality: | Monoclonal |
| ListPrice: | 335 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Threonine 573 of human RSK-1 was used as an immunogen. |
| Specificity: | This antibody detects RSK-1 phosphorylated at Threonine 573. |
| Cross Reactivity: | This antibody is reactive against Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful for Western Blot and Immunocytochemistry. |
| Background: | RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4). |
| Storage: | Aliquot and store at -20 °C. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. |
| Application Summary: | Western Blot 1:500, Immunocytochemistry 1:100-1:250, |
| Species Summary: | Hu, |
| Alternate Names: | Anti-90 kDa ribosomal protein S6 kinase 1 antibody, Anti-dJ590P13.1 antibody, Anti-HU 1 antibody, Anti-HU1 antibody, Anti-MAP kinase activated protein kinase 1a antibody, Anti-MAPKAPK1A antibody, Anti-p90 RSK1 antibody, Anti-p90S6K antibody, Anti-pp90RSK1 antibody, Anti-Ribosomal protein S6 kinase 90kD 1 antibody, Anti-Ribosomal protein S6 kinase 90kD polypeptide 1 antibody, Anti-Ribosomal protein S6 kinase 90kDa polypeptide 1 antibody, Anti-Ribosomal protein S6 kinase alpha 1 antibody, Anti-Ribosomal S6 kinase 1 antibody, Anti-RPS6K1 alpha antibody, Anti-Rps6ka1 antibody, Anti-RSK 1 antibody, Anti-RSK 1 p90 antibody, Anti-RSK antibody, Anti-RSK1 antibody, Anti-S6K alpha 1 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| Phosphorylated: | Thr573 |
| General References: | 1. Dalby, K.N. et al. J. Biol. Chem. 273, 1496-1505 (1998). 2. Frodin, M. and Gammeltoft, S. Mol. Cell. Endocrinol. 151, 65-77 (1999). 3. Lazar, D. F. et al. J. Biol. Chem. 270, 20801-20807 (1995). 4. Chen, R. et al. Proc. Natl. Acad. Sci. USA, 90, 10952-10956 (1993). |
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