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| Catalog Code: | NB110-62104 |
| Product Name: | Crk / p38 Phosphospecific Antibody |
| Product Description: | Rabbit Monoclonal anti-Crk / p38 (EPR269Y) [Tyr221] |
| Clone: | EPR269Y |
| Clonality: | Monoclonal |
| ListPrice: | 315 |
| Immunogen: | A phospho specific peptide corresponding to regions surrounding Tyrosine 221 was used as an immunogen. This antibody detects proteins phosphorylated at Y221. |
| Cross Reactivity: | This antibody is reactive against Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody is useful in Western Blot and Immunocytochemistry. |
| Background: | Crk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which play a key role in cellular signaling by mediating the construction of protein complexes and also by managing cell proliferation, differentiation, and migration (1). They are critical integrators of upstream signals for cell invasion and migration in human cancer cell lines. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers (2). In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth (3). Crk associates with ERM family proteins (including ezrin, radixin, and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4). |
| Storage: | Store at -20 °C. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. |
| Application Summary: | Western Blot 1:1000-1:2000, Immunocytochemistry 1:50-1:100, |
| Species Summary: | Hu, |
| Alternate Names: | Anti-Adapter molecule crk antibody; Anti-Avian sarcoma virus CT10 (v crk) oncogene homolog antibody; Anti-CRK antibody; Anti-CRKII antibody; Anti-CSAID Binding Protein 1 antibody; Anti-CSAID binding protein antibody; Anti-CSBP 1 antibody; Anti-CSBP 2 antibody; Anti-CSBP antibody; Anti-CSBP1 antibody; Anti-CSBP2 antibody; Anti-CSPB 1 antibody; Anti-CSPB1 antibody; Anti-Cytokine suppressive anti inflammatory drug binding protein antibody; Anti-EXIP antibody; Anti-MAP kinase MXI2 antibody; Anti-MAP kinase p38 alpha antibody; Anti-MAPK 14 antibody; Anti-MAPK14 antibody; Anti-MAX interacting protein 2 antibody; Anti-Mitogen Activated Protein Kinase 14 antibody; Anti-Mitogen activated protein kinase p38 alpha antibody; Anti-Mxi 2 antibody; Anti-Mxi2 antibody; Anti-p38 ALPHA antibody; Anti-p38 antibody; Anti-p38ALPHA antibody; Anti-PRKM14 antibody; Anti-PRKM15 antibody; Anti-Proto oncogene C crk antibody; Anti-RK antibody; Anti-SAPK 2A antibody; Anti-SAPK2A antibody; Anti-Stress Activated Protein Kinase 2A antibody; Anti-v crk avian sarcoma virus CT10 oncogene homolog antibody; Anti-v crk sarcoma virus CT10 oncogene homolog antibody; Anti-v crk sarcoma virus CT10 oncogene homolog (avian) antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.01% sodium azide |
| Phosphorylated: | Tyr221 |
| General References: | 1. Nishihara H, et al. Cancer Lett (1):55-61, 2002 2. Watanabe T, et al. Mol Cancer Res. (7):499-510, 2006 3. Rodrigues SP, et al. Mol Cancer Res. (4):183-94, 2005 4. Tsuda MJ, et al. Biol Chem. (45):46843-50, 2004 |
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more information: | company product webpage |