| CatalogCode: | | NB110-62102 |
| ProductName: | | ACHR-beta Antibody |
| Product Description: | | Rabbit Monoclonal anti-ACHR-beta (EP2067Y) |
| Clone: | | EP2067Y |
| Clonality: | | Monoclonal |
| Immunogen: | | A synthetic peptide corresponding to residues in the extracellular region of human Acetylcholine receptor subunit beta was used as an immunogen. |
| Specificity: | | This antibody is specific to acetylcholine receptor in human, rat, and mouse |
| CrossReactivity: | | This antibody is reactive against Human, Mouse, and Rat. Not yet tested in other species. |
| Packaging: | | 0.1 ml Rabbit ascites. |
| Uses: | | This antibody is useful for Western blot, Immunocytochemistry, and FACS. |
| Control: | | Human brain lysate |
| Background: | | The nicotinic acetylcholine receptor controls electrical signaling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. The gate is a constricting hydrophobic girdle at the middle of the lipid bi-layer, formed by weak interactions between neighboring inner helices. When acetylcholine enters the ligand-binding domain, it triggers rotations of the protein chains on opposite sides of the entrance to the pore (1). The widespread distribution of the beta subunit suggests it may serve as a common subunit in different AChR combinations in various brain regions. Regulation of the expression of beta subunit appears to be relatively unrestrained, with an apparent excess of protein synthesized in the cytoplasm relative to that which ultimately arrives at functional targets in the plasma membrane (2). |
| Storage: | | Aliquot and store at -20C. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. |
| ListPrice: | | 285 |
| AppSummary: | | FACS, WB, ICC |
| SpeciesSummary: | | Hu, Mu, Rt |
| ALTnames: | | Anti-Acetylcholine receptor protein beta chain precursor antibody; Anti-ACHRB antibody; Anti-Cholinergic receptor nicotinic beta polypeptide 1 (muscle) antibody; Anti-CHRNB antibody; Anti-Chrnb1 antibody; Anti-CMS1D antibody; Anti-CMS2A antibody; Anti-Nicotinic acetylcholine receptor beta subunit precursor antibody; Anti-SCCMS antibody |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Miyazawa A, et al. Nature 423(6943):949-55, 2003 2. Hill JA, et al. J Neurosci 13: 1551-68, 1993 |
| Target_Reg: | | extracellular |
| more information: | | company product webpage |
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