| CatalogCode: | NB110-62087 |
| ProductName: | LOX1 Antibody |
| Product Description: | Rabbit Polyclonal anti-LOX1 |
| Clonality: | Polyclonal |
| Immunogen: | Antisera to LOX1 were raised by repeated immunisations of rabbits with purified peptide against the C-terminal (extracellular) region of LOX1 |
| Specificity: | This antibody is specific for the C-terminal (extracellular) region of LOX1 |
| CrossReactivity: | This antibody is reactive against Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Whole antisera Rabbit antisera. |
| Uses: | This antibody is useful in ELISA and Immunofluorescence. |
| Background: | LOX 1 belongs to the C type lectin like protein super family. This unique scavenger receptor plays important roles in atherogenesis. Like other scavenger receptors, LOX 1 has a wide spectrum of physiological ligands, including OxLDL, anionic phospholipids, aged/apoptotic cells, activated platelets, and bacteria. The LOX 1 gene is a so called immediate early gene that is dynamically modulated by several factors in vitro and in vivo. LOX 1 expression is induced by stimuli such as inflammatory cytokines, OxLDL, TNF alpha, TGF beta, and ANG II in vitro, and several proatherogenic factors in vivo. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host_Name: | Rabbit |
| Buffer: | 1% bovine serum albumin |
| ListPrice: | 285 |
| AppSummary: | ELISA, IF |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CLEC8A antibody; Anti-hLOX 1 antibody; Anti-Lectin like oxidized LDL receptor 1 antibody; Anti-Lectin like oxLDL receptor 1 antibody; Anti-Lectin type oxidized LDL receptor 1 antibody; Anti-OLR1 antibody; Anti-Ox LDL receptor 1 antibody; Anti-Oxidised low density lipoprotein (lectin like) receptor 1 antibody; Anti-Oxidized low density lipoprotein receptor 1 antibody; Anti-Oxidized low density lipoprotein receptor 1 soluble form antibody; Anti-SCARE1 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Chen, M. et al. (2002) LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol. Ther. 95: 89-100 2. Li, D. et al. (2003) LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Atherosclerosis, Thrombosis and Vascular Biology; 23: 816-821 3. Morawietz, H. et al. (1999) Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein. Circulation; 100: 899-902 4. Sawamura, T. et al. (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature; 386: 73-77 5. Yoshida, H. et al. (1998) Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptor. Biochem. J. 334: 9-13 |
| Target_Reg: | C-terminal |