| CatalogCode: | NB110-62076 |
| ProductName: | FGFR1 Antibody |
| Product Description: | Rabbit Polyclonal anti-FGFR1 |
| Clonality: | Polyclonal |
| Immunogen: | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human FGFR that contains tyrosine 653 and 654. The sequence is conserved in human, mouse and rat. |
| Specificity: | Human, mouse and rat. This antibody may cross-react with phosphorylated FGFR2 [pYpY656/657] and FGFR3 [pYpY647/648] as determined by peptide competition. |
| CrossReactivity: | This antibody is reactive against Human, Mouse, and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody has been used in Western blotting and Immunoflourescence. |
| Control: | Thyroid carcinoma cells (TT cells), neuroblastoma cells (Neuro 2A) cells, FGF2-treated 3T3 fibroblas |
| Background: | Fibroblast growth factor receptor 1 (FGFR1) is a member of the fibroblast growth factor tyrosine kinase receptor family (FGFR1, FGFR2, FGFR3, and FGFR4) and plays diverse roles in various developmental and physiological processes. FGFR1 is activated upon ligand binding to its extracellular domain, resulting in its dimerization, and activation of the kinase domain, leading to its phosphorylation at specific tyrosine sites. FGFR1 contains at least seven tyrosine phosphorylation sites (Tyr 463, Tyr 583, Tyr 585, Tyr 653, Tyr 654, Tyr 730 and Tyr 766). Phosphorylation of tyrosines 653 and 654 in the activation domain is critical for FGFR1 catalytic activity and for mediating its biological responses. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Rabbit polyclonal immunoglobulin in Dulbecco's phosphate buffered saline (without Mg2+ and Ca2+), pH |
| ListPrice: | 295 |
| AppSummary: | IF, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | Anti-Basic fibroblast growth factor eceptor 1 antibody; Anti-bFGF R antibody; Anti-BFGFR antibody; Anti-C FGR antibody; Anti-CD 331 antibody; Anti-CD331 antibody; Anti-CD331 antigen antibody; Anti-CEK antibody; Anti-FGFBR antibody; Anti-FGFR 1 antibody; Anti-Fibroblast growth factor receptor 1 antibody; Anti-FLG antibody; Anti-FLG protein antibody; Anti-FLJ14326 antibody; Anti-FLT 2 antibody; Anti-FLT2 antibody; Anti-Fms like tyrosine kinase 2 antibody; Anti-Fms related tyrosine kinase 2 antibody; Anti-Fms related tyrosine kinase 2 Pfeiffer syndrome antibody; Anti-H2 antibody; Anti-H3 antibody; Anti-H4 antibody; Anti-H5 antibody; Anti-HBGFR antibody; Anti-Heparin binding growth factor receptor antibody; Anti-Hydroxyaryl protein kinase antibody; Anti-KAL 2 antibody; Anti-KAL2 antibody; Anti-MFR antibody; Anti-N SAM antibody; Anti-N sam tyrosine kinase antibody; Anti-Protein tyrosine kinase antibody; Anti-Tyrosylprotein kinase antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. St. Bernard, R., et al. (2005) Fibroblast growth factor receptors as molecular targets in thyroid carcinoma. Endocrinology 46(3):1145-1153. 2. Gowardhan, B., et al. (2005) Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer. Br. J. Cancer 92(2):320-327. 3. Wang, F., et al. (2004) Chronic activity of ectopic type 1 fibroblast growth factor receptor tyrosine kinase in prostate epithelium results in hyperplasia accompanied by intraepithelial neoplasia. Prostate 58(1):1-12. 4. Hajihosseini, M.K., et al. (2004) Skeletal development is regulated by fibroblast growth factor receptor 1 signalling dynamics. Development 131(2):325-335. 5. Billottet, C., et al. (2004) Targets of fibroblast growth factor 1 (FGF-1) and FGF-2 signaling involved in the invasive and umorigenic behavior of carcinoma cells. Mol. Biol. Cell 15(10):4725-4734. 6. Freeman, K.W., et al. (2003) Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation. Cancer Res. 63(19):6237-6243. 7. Stachowiak, M.K., et al. (1996) Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells. Mol. Biol. Cell 7(8):1299-1317. 8. Campbell, J.S., et al. (1995) Differential activation of mitogen-activated protein kinase in response to basic fibroblast growthfactor in skeletal muscle cells. Proc. Nat'l. Acad. Sci. USA 92(3):870-874. |
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