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| Catalog Code: | NB110-61686 |
| Product Name: | HB9 Antibody |
| Product Description: | Sheep Polyclonal anti-HB9 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | A 20 amino acid synthetic HB9 peptide (HAPADRLRAESPSPPRLLAAHC-NH2), conjugated to Blue Carrier Protein. |
| Specificity: | Specific for HB9. Confirmed by Immunohistochemical analysis of Normal Term and First Trimester human Placenta as well as western blot analysis of mouse Neuroblastoma and Spinal Cord cells (NSC-34). |
| Cross Reactivity: | This antibody is reactive against Human and Mouse. Not yet tested in other species. |
| Packaging: | 0.02 mg Affinity purified Sheep antisera. |
| Uses: | ELISA, Immunohistochemistry and Western Blot. |
| Background: | The homeobox gene Hb9/Hlxb9, is expressed selectively by motor neurons (MNs) in the developing vertebrate CNS. Hb9, which encodes a factor central to MN development regulates neuronal fate by restricting expression of Lim3 and Even-skipped (Eve), two homeodomain (HD) proteins required for development of distinct neuronal classes. In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons. Hb9 is also a transcription factor expressed in lymphoid and pancreatic tissue. In humans, HB9 mutation causes an autosomal dominant form of sacral agenesis. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Host Name: | Sheep |
| Application Summary: | ELISA 1:500-1:6500, immunohistochemistry 1:500-1:2000, Western Blot 1:1000, |
| Species Summary: | Hu, Mu, |
| Alternate Names: | Anti-HB 9 antibody; Anti-HB9 antibody; Anti-HLXB 9 antibody; Anti-HLXB9 antibody; Anti-Homeo box HB9 antibody; Anti-Homeobox HB9 antibody; Anti-Homeobox protein HB9 antibody; Anti-HOXHB9 antibody; Anti-Sacral agenesis autosomal dominant (Currarino triad) antibody; Anti-SCRA 1 antibody; Anti-SCRA1 antibody |
| Package Size: | 0.02 mg |
| Preservative: | No Preservatives |
| Notes Main: | Reconstitute with addition of 0.02 ml of sterile water. |
| General References: | 1. Hollington, P. et al (2004) Anti Cancer Research. 24: 955-962. 2. Neufing, P. J. et al (2003) Anti Cancer Research. 23: 1479-1488. 3. Matusica, D. et al (2007) Journal of Neuroscience Reserach. (in Press) |
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