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| Catalog Code: | NB110-61650 |
| Product Name: | ChAT Antibody |
| Product Description: | Sheep Polyclonal anti-ChAT |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | A 22 amino acid synthetic peptide from porcine ChAT, coupled to keyhole limpet hemocyanin. The peptide sequence is H-GLFSSYRLPGHTQDTLVAQKSS-NH2. |
| Specificity: | Will stain colinergic neurons in rat, guinea pig and rabbit central and peripheral nervous systems. Not yet tested agains human material but rabbit antibodies against the same peptide have been shown to react against primate and human enzyme. |
| Cross Reactivity: | This antibody is reactive against Human, Rat, Rabbit, and Guinea Pig. Not yet tested in other species. |
| Packaging: | Affinity purified Sheep antisera. |
| Uses: | Immunohistochemisty and western blot. |
| Background: | Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfunction of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer's disease, Down and Rett syndromes. Choline acetyltransferase recruits choline for the synthesis of acetylcholine at preganglionic parasympathetic and sympathetic fibres. It is also present at parasympathetic postganglionic fibres. |
| Storage: | Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Host Name: | Sheep |
| Application Summary: | immunohistochemistry , Western Blot , |
| Species Summary: | Hu, Rt, Rb, Gp, |
| Alternate Names: | Anti-acetyl CoA:choline O acetyltransferase antibody, Anti-ChAT antibody, Anti-CHOACTase antibody, Anti-Choline acetylase antibody, Anti-Choline O acetyltransferase antibody, Anti-CMS1A antibody, Anti-CMS1A2 antibody |
| Preservative: | No Preservatives |
| General References: | Benecke et al. (1993) J. Neurochem 61: 804-811. |
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more information: | company product webpage |