| Catalog Code: | NB110-61646 |
| Product Type: | Primary Antibody |
| Product Name: | Nucleophosmin, mutant Antibody |
| List Price: | 285 |
| Clonality: | Polyclonal |
| Gene ID: | 4869 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-Nucleophosmin, mutant - AML Marker |
| Cross Reactivity: | Human. Other species have not been tested. |
| Species Summary: | Hu |
| Background: | Nucleophosmin (NPM) is a multi-functional protein that is involved in many cellular activities including cell growth, proliferation and transformation. It is frequently overexpressed in solid tumors, and has recently been found to be mutated and aberrantl |
| Alternate Names: | anti-mNPM1 antibody, anti-mNPM antibody, anti-B23 antibody, anti-numatrin antibody, anti-NO38 antibody |
| Immunogen: | A synthetic peptide made to a C-terminal region of human mutant nucleophosmin (exact sequence is within residues 250-298). |
| Localization: | Nucleophosmin typically resides in the nucleus. However, in patients with acute myelogenous leukemia (AML) it mutates and localizes to the cytoplasm. |
| Purity: | Affinity purified |
| Buffer: | 100 mM glycine, 65 mM Tris, pH 7.0 in 50% glycerol |
| Preservative: | No preservative |
| Packaging: | 0.1 ml Affinity purified Rabbit antisera. |
| Package Size: | 0.1 ml |
| Concentration: | 0.3 mg/ml |
| Uses: | This antibody is useful for Western blot analysis where a band can be seen at ~37 kDa. It may also be useful for immunoprecipitation, immunofluorescence, immunohistochemistry (paraffin), and FACS analysis. |
| Application Summary: | FACS, IF, IP, WB, IHC-P |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| General References: | 1. Falini, Brunangelo, et al. New Eng. J. of Med. 352:254-66 (2005). 2. Grisendi, Silvia, et al. Nat. Rev. 6:493-505 (2006). |