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| Catalog Code: | NB110-61574SS |
| Product Name: | Lactoperoxidase Antibody |
| Product Description: | Rabbit Polyclonal anti-Lactoperoxidase, Sample Size |
| Clonality: | Polyclonal |
| ListPrice: | 100 |
| Gene ID: | 4025 |
| Concentration: | 1.5 mg/ml |
| Immunogen: | Synthetic peptide made to a C-terminal portion of the human protein (within residues 650-712). [Swiss-Prot# P22079] |
| Cross Reactivity: | Human. Other species have not been tested. |
| Packaging: | 0.025 ml peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot analysis where a band is seen at ~100 kDa. Caution, do not use milk for the blocking or dilution buffers. |
| Localization: | Secreted, extracellular space. |
| Background: | Lactoperoxidase is an antibacterial agent in cow milk. The heme protein lactoperoxidase (LPO), also referred to as salivary peroxidase (SPO), is an oxidoreductase secreted into milk. LPO belongs to the XPO subfamily of the peroxidase family. It is expressed in mammary and salivary glands, and in the presence of H2O2, LPO acts as a catalyst for the oxidation of many phenols and aromatic amines. It is crucial for protecting the lactating mammary gland and intestinal tract of newborn infants against microorganisms. LPO binds one calcium ion per heterodimer and one heme B (iron-protoporphyrin IX) group covalently per heterodimer. The LPO gene, which spans 28 kb, is similar in gene organization and sequence to the peroxidase genes MPO and EPX, suggesting the possibility that these genes evolved from a common ancestral gene. The LPO and MPO genes are arranged in a tail-to-tail manner on chromosome 17q23.1. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | peptide affinity purified |
| Host Name: | Rabbit |
| Buffer: | PBS, 30% glycerol |
| Application Summary: | Western Blot 0.5 - 2.0 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-LPO antibody, anti-EC 1.11.17 antibody, anti-salivary peroxidase antibody, anti-SPO antibody, anti-SAPX antibody |
| Package Size: | 0.025 ml |
| Preservative: | 0.1% sodium azide |
| Homology: | 100% homology with human, mouse, hamster, sheep and goat. 92% homology with bovine. |
| General References: | 1. Wijkstrom-Frei, C., et al. Am. J. Clin. Nutr. 73: 984-989 (2003) 1. Shin, K., et al. Am. J. Respir.Cell Mol. Biol. 29: 206-212 (2001) 1. Shin, K., et al. J. Nutr. Biol. Chem. 11(2): 94-102 (2000) |
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