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| Catalog Code: | NB110-60998 |
| Product Name: | E Selectin Antibody |
| Product Description: | Mouse Monoclonal anti-E Selectin (MM0032-9E7) |
| Clone: | MM0032-9E7 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant E-selectin protein. |
| Cross Reactivity: | This antibody is reactive against human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | This antibody recognizes human E-selectin in western blot. No cross reactivity to ICAM, and VCAM. |
| Background: | CD62E is also known as endothelial leukocyte adhesion molecule 1 (ELAM1) or E selectin. It is a type I membrane protein that belongs to the selectin family of surface molecules (along with CD62L and CD62P). Selectins are C type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. CD62E (E selectin) is an endothelial cell specific selectin that is expressed on cytokine induced endothelial cells only after activation with proinflammatory cytokines. In vitro experiments have shown that IL1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of CD62E in an NFkB dependent signalling cascade. CD62E has been associated with blood vessel endothelium in diverse inflammatory situations. The main ligands recognised by CD62E are oligosaccharides related to sialyl lewis xx. This antibody inhibits neutrophil adhesion to E-selectin and to P-selectin. E-selectin (ELAM-1) is expressed on the surface of activated endothelial cells. |
| Storage: | Reconstitute in 0.5 ml PBS. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2 |
| Host Name: | Mouse |
| Buffer: | PBS |
| Application Summary: | immunohistochemistry 1:50-1:200, Western Blot 1:500-1:2000, |
| Species Summary: | Hu, |
| Alternate Names: | Anti-CD 62E antibody; Anti-CD62E antigen antibody; Anti-E-selectin antibody; Anti-Eselectin antibody Anti-ELAM 1 antibody; Anti-ELAM antibody; Anti-ELAM1 antibody; Anti-Endothelial adhesion molecule 1 antibody; Anti-Endothelial leukocyte adhesion molecule 1 antibody; Anti-ESEL antibody; Anti-LECAM 2 antibody; Anti-LECAM2 antibody; Anti-Leukocyte endothelial cell adhesion molecule 2 antibody; Anti-SELE antibody; Anti-Selectin E antibody; Anti-Selectin-E antibody; Anti-SelectinE antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservatives |
| Notes Main: | This antibody has only been tested on paraffin for immunohistochemistry. |
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