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| Catalog Code: | NB110-60997 |
| Product Name: | EPO Receptor Antibody |
| Product Description: | Mouse Monoclonal anti-EPO Receptor (MM0031-6G7) |
| Clone: | MM0031-6G7 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant EPO receptor (extracellular domain). |
| Cross Reactivity: | This antibody is reactive against human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | This antibody recognizes human EPO receptor in western blot and immunohistochemistry-paraffin. |
| Background: | The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis. |
| Storage: | Reconstitute in 0.5 ml PBS. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2 |
| Host Name: | Mouse |
| Buffer: | PBS |
| Application Summary: | Western Blot 1:1000-1:2000, Immunohistochemistry-Paraffin 1:50-1:300, |
| Species Summary: | Hu, |
| Alternate Names: | Anti-EPO R antibody; Anti-EPOR antibody; Anti-Erythropoietin receptor antibody; Anti-Erythropoietin receptor precursor Anti-antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservatives |
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