| CatalogCode: | NB110-60928 |
| ProductName: | ATG16L1 Antibody |
| Product Description: | Rabbit Polyclonal anti-ATG16L1 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide within residues 1-100 of the human protein. [Swiss-Prot# Q676U5] |
| CrossReactivity: | Human and mouse. Weakly in rat. Other species not yet tested. |
| Packaging: | 0.1 ml peptide affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western blot analysis, where 2 doublets are seen. |
| Localization: | Cytoplasm. Preautophagosomal structure, preautophagosomal structure membrane, peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. |
| Control: | HeLa whole cell lysate |
| Background: | Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is essential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane. There are 5 isoforms of this protein (in human), with theoretical molecular weights ranging from ~19-68 kDa. |
| Storage: | Store at 4C for short-term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| Buffer: | PBS, 30% glycerol |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-apg16l beta antibody, anti-apg16 autophagy 16like s cerevisiae antibody, anti-wdr30 antibody, anti-wd repeat domain 30 antibody, anti-atg16l antibody, anti-atg16 autophagy related 16like s cerevisiae antibody, anti-apg16 autophagy 16like antibody, anti-apg16l antibody, anti-ATG16 autophagy related 16-like 1 antibody |
| PackageSize: | 0.1 ml |
| Homology: | 100% homology with human and monkey proteins. 94% homology with rat, bovine, canine and mouse proteins. |
| Gene_Id: | 55054 |
| Omim_ID: | NB110-60928SS |