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| Catalog Code: | NB110-60508 |
| Product Name: | Desmin Antibody |
| Product Description: | Mouse Monoclonal anti-Desmin (10H7D2) |
| Clone: | 10H7D2 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Ni-NTA purified truncated recombinant Desmin expressed in E. Coli strain BL21 (DE3) |
| Cross Reactivity: | Human |
| Packaging: | 0.1 mg Mouse ascites. |
| Uses: | This antibody is useful in Western Blot, IHC(P), IHC(F), and ELISA. |
| Background: | Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response. |
| Storage: | Store at 4C for short term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Application Summary: | ELISA 1: 10,000, Western Blot 1: 1,000- 1: 2,000 , Immunohistochemistry-Paraffin 1: 1,000- 1: 2,000 , Immunohistochemistry-Frozen 1: 1,000- 1: 2,000 |
| Species Summary: | Hu, |
| Package Size: | 0.1 mg |
| General References: | 1. Felix R. Shardonofsky, Yassemi Capetanaki, and Aladin M. Boriek Am J Physiol Lung Cell Mol Physiol, May 2006; 290: L890 - L896 2. Xupei Huang, Jian Li, Dalton Foster Experimental Biology and Medicine, Dec 2002; 227: 1039 |
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