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| Catalog Code: | NB110-60505 |
| Product Name: | TYK2 Antibody |
| Product Description: | Mouse Monoclonal anti-TYK2 (8G8E9) |
| Clone: | 8G8E9 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3) |
| Cross Reactivity: | Human |
| Packaging: | 0.1 ml Ascites Mouse ascites. |
| Uses: | This antibody is useful in Western Blot and ELISA. |
| Background: | Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance. |
| Storage: | Store at 4C for short term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Application Summary: | ELISA 1:10000, Western Blot 1:500-1:2000 |
| Species Summary: | Hu, |
| Package Size: | 0.1 ml |
| General References: | 1. Michael H. Shaw, Gordon J. Freeman, Mark F. Scott J. Immunol., Jun 2006; 176: 7263-7271 2. Yohei Seto, Hiroshi Nakajima, Akira Suto J. Immunol., Jan 2003; 170: 1077 3. Dagmar Stoiber, Boris Kovacic, Christian Schuster J. Clin. Invest., Dec 2004; 114: 1650-1658 |
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