| CatalogCode: | NB110-60503 |
| ProductName: | GSK3 Antibody |
| Product Description: | Mouse Monoclonal anti-GSK3 (6G2F1-6G2F2) |
| Clone: | 6G2F1-6G2F2 |
| Clonality: | Monoclonal |
| Immunogen: | Ni-NTA purified truncated recombinant GSK3 alpha expressed in E. Coli strain BL21 (DE3) |
| CrossReactivity: | Human |
| Packaging: | 0.1 ml Mouse ascites. |
| Uses: | This antibody is useful for Western Blot, IHC(P), IHC(F), and ELISA. |
| Background: | GSK3 alpha (Glycogen synthase kinase 3 alpha), with 483-amino acid protein (about 53kDa), belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily,GSK3 subsubfamily, which also includes GSK3 beta.GSK3 is a multifunctional serine/threonine kinase that is usually inactivated by serine phosphorylation in response to extracellular cues. GSK3 is a key regulator of numerous signalling pathways, including cellular responses to Wnt, receptor tyrosine kinases and G-protein-coupled receptors and is involved in a wide range of cellular processes, ranging from glycogen metabolism to cell cycle regulation and proliferation.GSK3 alpha is implicated in the control of several regulatory proteins including glycogen synthase and transcription factors. |
| Storage: | Store at 4C for short term. Aliquot and store at -20C for long term. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Host_Name: | Mouse |
| ListPrice: | 325 |
| AppSummary: | ELISA, WB, IHC-P, IHC-Fr |
| SpeciesSummary: | Hu |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Bradley W. Doble and James R. Woodgett J. Cell Sci., Apr 2003; 116: 1175 2. C. Laura Sayas , Aafke Ariaens, Bas Ponsioen Mol. Biol. Cell, Apr 2006; 17: 1834 ¨C 1844 |
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