| CatalogCode: | | NB110-60496 |
| ProductName: | | Lck Antibody |
| Product Description: | | Mouse Monoclonal anti-Lck (8E5F9, 4B2C7) |
| Clone: | | 8E5F9, 4B2C7 |
| Clonality: | | Monoclonal |
| Immunogen: | | Ni-NTA purified truncated recombinant Lck expressed in E. Coli strain BL21 (DE3) |
| CrossReactivity: | | Human |
| Packaging: | | 0.1 ml Ascites Mouse ascites. |
| Uses: | | This antibody is useful in Western Blot,and ELISA. |
| Background: | | Lck(lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection. |
| Storage: | | Store at -20 degrees. |
| Purity: | | Ascites |
| Isotype: | | IgG2a |
| Host_Name: | | Mouse |
| ListPrice: | | 325 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| PackageSize: | | 0.1 ml |
| GeneralRef: | | 1. Mingjian Shi, John C. Cooper, Chao-Lan Yu Mol. Cancer Res., Jan 2006; 4: 39 ¨C 45 2. Robert F. Stachlewitz, Michelle A. Hart, Brian Bettencourt J. Pharmacol. Exp. Ther., Oct 2005; 315: 36 ¨C 41 3. Ibrahim Y. Hawash, Kamala P. Kesavan, Anthony I. Magee J. Biol. Chem., Feb 2002; 277: 5683 ¨C 5691 |
| more information: | | company product webpage |
|