| CatalogCode: | NB110-60492 |
| ProductName: | SNCA Antibody |
| Product Description: | Mouse Monoclonal anti-SNCA (2B2D1, 2B2A11) |
| Clone: | 2B2D1, 2B2A11 |
| Clonality: | Monoclonal |
| Immunogen: | Ni-NTA purified truncated recombinant SNCA expressed in E. Coli strain BL21 (DE3) |
| CrossReactivity: | Human |
| Packaging: | 0.1 ml Ascites Mouse ascites. |
| Uses: | This antibody is useful for Western Blot, IHC(P), IHC(F), and ELISA. |
| Background: | Alpha-synuclein (SNCA), with 140-amino acid protein (about 15kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy. |
| Storage: | Store at -20 degrees |
| Purity: | Ascites |
| Host_Name: | Mouse |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB, IHC-P, IHC-Fr |
| SpeciesSummary: | Hu |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. J. Johnson, S. M. Hague, M. Hanson Neurology, Aug 2004; 63: 554 ¨C 556 2. Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie Protein Pept Lett. 2006;13(4):385-90. |
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