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| Catalog Code: | NB110-60491 |
| Product Name: | Dynamin-1 Antibody |
| Product Description: | Mouse Monoclonal anti-Dynamin-1 (3G4B6) |
| Clone: | 3G4B6 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Ni-NTA purified truncated recombinant Dynamin-1 expressed in E. Coli strain BL21 (DE3) |
| Cross Reactivity: | Human |
| Packaging: | 0.1 ml Mouse ascites. |
| Uses: | This antibody is useful for Western Blot, IHC(P), IHC(F), and ELISA. |
| Background: | Dynamin-1 (Dyn1), with 864-amino acid protein (about 95kDa), belongs to the dynamin family. Dynamin-1 (neuron-specific), dynamin-2 (ubiquitously expressed), and dynamin-3 (expressed only in the testis, brain, and lung), constitute the dynamin family. Members of the dynamin family are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin-1 is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C. Dynamin-1 is a large GTPase enzyme required in membrane constriction and fission during multiple forms of endocytosis. Dynamin-1 is also a key molecule required for the recycling of synaptic vesicles in neurons, and it has been known that dynamin-1 gene expression is induced during neuronal differentiation. |
| Storage: | Store at -20 degrees |
| Purity: | Ascites |
| Isotype: | IgG2a |
| Host Name: | Mouse |
| Application Summary: | ELISA 1: 10,000 , Western Blot 1: 500- 1: 2,000 , Immunohistochemistry-Paraffin 1: 500- 1: 2,000 , Immunohistochemistry-Frozen 1: 500- 1: 2,000 |
| Species Summary: | Hu, |
| Package Size: | 0.1 ml |
| General References: | 1.Annie Quan and Phillip J. Robinson Methods Enzymol. 2005; 404:556-69. 2.Jiyun Yoo, Moon-Jin Jeong, Byoung-Mog Kwon J. Biol. Chem., Mar 2002; 277: 11904 ¨C 11909 |
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