| CatalogCode: | NB110-60490 |
| ProductName: | ZAP70 Antibody |
| Product Description: | Mouse Monoclonal anti-ZAP70 ( 3D2A4) |
| Clone: | 3D2A4 |
| Clonality: | Monoclonal |
| Immunogen: | Ni-NTA purified truncated recombinant ZAP70 expressed in E. Coli strain BL21 (DE3) |
| CrossReactivity: | Human |
| Packaging: | 0.1 ml protein A purified Mouse ascites. |
| Uses: | This antibody is useful for Western Blot, IHC(P), IHC(F), and ELISA. |
| Background: | ZAP70(zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Zap70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the zap-70 gene. ZAP-70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia. |
| Storage: | Store at -20 degrees. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| ListPrice: | 325 |
| AppSummary: | ELISA, WB, IHC-P, IHC-Fr |
| SpeciesSummary: | Hu |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1.Sigal Gelkop , Gerrald D. Gish, Yael Babichev J Immunol. 2005 Dec 15;175(12):8123-32 2.Joaquim Carreras , Neus Villamor ,Lluis Colomo J Pathol. 2005 Mar;205(4):507-13 3.Claire Hivroz Med Sci (Paris). 2005 Feb;21(2):150-5 |
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