| CatalogCode: | NB110-6010 |
| ProductName: | Steroidogenic Factor 1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Steroidogenic Factor 1 |
| Clonality: | Polyclonal |
| Immunogen: | Purified :SF-1 fusion protein corresponding to the ligand-binding domain. (The exact immunogen sequence is "commercially sensitive"). |
| Specificity: | Detects Steroidogenic Factor 1 (SF-1) from mouse tissues as well as recombinant mouse SF-1. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Immunohistochemistry: use at a concentration of 1 ug/ml.Western Blot: use at a concentration of 0.5 ug/ml.Not tested in other applications. Optimal dilution / concentration should be determined by the end user.By Western blot, this antibody detects a protein representing a GST:SF-1 fusion protein overexpressed in E. coli. |
| Localization: | Cell Membrane |
| Control: | WB: SF-1 fusion protein overexpressed in E. coli. IHC: mouse ovary sections |
| Background: | Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor involved in organ development and differentiation of the endocrine system. SF-1 has been shown to be essential for fetal development of the hypothalamus, pituitary gland, gonads, and the adrenal gland. SF-1 has been shown to promote transcriptional activity of many steroidogenic enzymes from the cytochrome P450 family. SF-1 contains two activation function domains, designated AF1 and AF2, common to many nuclear steroid receptors which have been shown to be necessary for interaction with other nuclear receptors as well as coactivators and corepressors including steroid receptor coactivator-1 (SRC-1), glucocorticoid receptor interacting protein 1 (GRIP1), cAMP response element binding protein (CREB) binding protein (CBP) and silencing mediator of retinoid acid and thyroid hormone receptor (SMRT). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS, 1 mg/ml BSA. |
| ListPrice: | 295 |
| AppSummary: | ChIP, IHC-Fr, IF, WB, ICC, IHC-P |
| SpeciesSummary: | Mu, Rt |
| ALTnames: | anti-SF-1 antibody, anti-SF1 antibody, anti-NR5A1 antibody, anti-FTZF1 antibody |
| ProteinTarget: | Steroidogenic Factor 1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Endo., 144(8): 3598-3610, 2003. Endocrinology May 2005 doi:10.1210/en.2004-1643 Endocrinology, doi:10.1210/me.2005-0199, Jan 2006 Endocrinology, Vol 144: 3598-3610, Aug 2003 Fron. Neuroendocrin. 20: 199-223, 1999. Genes Develop., 8: 2302-2312, 1994. Mol. Endocrin., 12: 290-301, 1998. |
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