| CatalogCode: | NB110-60005 |
| ProductName: | Cytokeratin 19 Antibody |
| Product Description: | Mouse Monoclonal anti-Cytokeratin 19 (236-11791) |
| Clone: | 236-11791 |
| Clonality: | Monoclonal |
| Immunogen: | Mammary organoids |
| Specificity: | Cytokeratin peptide 19 (40 kDa) in human tissue. |
| CrossReactivity: | This antibody is reactive against human. |
| Packaging: | 0.1 ml protein A purified Mouse ascites. |
| Uses: | Suitable for use in Western blot, Immunohistochemistry (paraffin sections), Immunoprecipitation and Immunocytochemistry. |
| Background: | his protein is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. Keratin 19 is not expressed in hepatocytes, therefore, antibody to keratin 19 is useful in the identification of liver metastasis. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS, pH 7.4 |
| ListPrice: | 295 |
| AppSummary: | IP, WB, ICC, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CK 19 antibody; anti-ck19 antibody anti-Cytokeratin 19 antibody; anti-k19 antibody; anti-k1cs antibody; anti-Keratin 19 antibody; anti-Keratin type i 40kD antibody; anti-Keratin type I cytoskeletal 19 antibody; anti-krt19 antibody; anti-mgc15366 antibody |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Bartek, J., et al., (1985), A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins, J. Cell Sci., 75, 17-33 2. Bartek, J., et al., (1985), Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours, Int. J. Cancer, 36(3), 299-306 |
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