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| Catalog Code: | NB110-59963 |
| Product Name: | TRAF3 Antibody |
| Product Description: | Rabbit Monoclonal anti-TRAF3 (EP1730Y) |
| Clone: | EP1730Y |
| Clonality: | Monoclonal |
| ListPrice: | 320 |
| Specificity: | A synthetic peptide corresponding to residues on the N-terminus of human TRAF3 was used as an immunogen. |
| Cross Reactivity: | This antibody is reactive against human. |
| Packaging: | 0.1 ml |
| Uses: | This antibody works in WB, IHC, ICC, FC. The molecular weight in WB is 64 kDa. |
| Background: | Human TRAF-3 is a signaling molecule that interacts with the cytoplasmic tails of CD40 and other TNF-receptor family members (1). The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-kappaB and mitogen-activated protein kinases. Furthermore, TRAF proteins serve as a docking platform for a variety of regulators of these signalling pathways and are themselves often regulated at the transcriptional and posttranslational level (2). The CD40 fragment binds as a hairpin loop across the surface of the TRAF domain. Residues shown by mutagenesis and deletion analysis to be critical for TRAF3 binding are involved either in direct contact with TRAF3 or in intramolecular interactions that stabilize the hairpin (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | immunohistochemistry 1:50, Western Blot 1:500, Immunocytochemistry 1:100 250, FC 1:20 |
| Species Summary: | Hu, |
| Alternate Names: | anti-CD40 receptor-associated factor 1 antibody, anti-CRAF1 antibody, CD40-binding protein antibody, anti-CD40BP antibody, anti-LMP1-associated protein antibody, anti-LAP1 antibody, anti-CAP-1 antibody |
| Package Size: | 0.1 ml |
| General References: | 1. van Eyndhoven WG, et al. Mol Immunol 35(18):1189-206 1998 2. Wajant H, et al. Cell Signal 13(6):389-400, 2001 3. Ni CZ, et al. Proc Natl Acad Sci 97(19):10395-9, 2000 |
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