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| Catalog Code: | NB110-59962 |
| Product Name: | TIMP1 Antibody |
| Product Description: | Rabbit Monoclonal anti-TIMP1 (EP1549RY) |
| Clone: | EP1549RY |
| Clonality: | Monoclonal |
| ListPrice: | 320 |
| Specificity: | A synthetic peptide corresponding to residues in the C-terminal region of human TIMP-1 was used as immunogen. |
| Cross Reactivity: | This antibody is reactive against human. |
| Packaging: | .1 ml Rabbit ascites. |
| Uses: | This antibody works in WB, where a band is seen ~28 kDa. |
| Background: | Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a stromal factor which forms complexes with various members of matrix metalloproteinases (MMPs) and irreversibly inactivates them. A multifunctional glycoprotein, TIMP-1 is one of the four members of TIMP family (TIMP 1-4) which exhibits 50% sequence similarity and expressed in wide variety of cells (1). TIMP-1 TIMP-1 binds non-covalently in a 1:1 stoichiometric fashion to the active form of MMPs thereby inhibiting the proteolytic activity of these enzymes. Including inhibitory function, other studies have proposed growth protion, anti-apoptotic, anti- and pro-angiogenic functions for TIMP-1. TIMP-1 expression has been observed in poor clinical outcome in many cancer types, making it ideal prognostic marker in various cancer (2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | Western Blot 1:100-500, |
| Species Summary: | Hu, |
| Alternate Names: | anti-TIMP-1antibody, anti-Erythroid-potentiating activity antibody, anti-EPA antibody, anti-Tissue inhibitor of metalloproteinasesantibody, anti-Fibroblast collagenase inhibitor antibody, anti-Collagenase inhibitor antibody |
| Package Size: | .1 ml |
| General References: | 1. Schrohl AS et al Endocrine-Related Cancer 12 (2) 215-227, 2005. 2. Schrohl AS et al. Clinical Cancer Research 10 2289-2298, 2004. |
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