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| Catalog Code: | NB110-59956 |
| Product Name: | Noggin Antibody |
| Product Description: | Rabbit Polyclonal anti-Noggin |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues on human noggin was used as an immunogen. |
| Cross Reactivity: | This antibody is reactive against human. |
| Packaging: | 0.1 ml IgG purified Rabbit antisera. |
| Uses: | This antibody works in WB, FC, IP. The molecular weight in WB is 23 kDa. |
| Background: | The secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members of the transforming growth factor beta superfamily of signaling proteins (TGFbeta-FMs), such as BMP4. By diffusing through extracellular matrices more efficiently than TGFbeta-FMs, noggin may have a principal role in creating morphogenic gradients. Findings report that noggin is essential for joint formation and suggest that NOG requirements during skeletogenesis differ between species and between specific skeletal elements within species (1). Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs (2). The structure of the antagonist Noggin bound to BMP-7, shows that noggin inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors (3). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | immunoprecipitation 1:10, Western Blot 1:500 1000, FC 1:10 |
| Species Summary: | Hu, |
| Package Size: | 0.1 ml |
| General References: | 1. Gong Y, et al. Nat Genet. 21(3):302-4, 1999. 2. Brunet LJ, et al. Science 280(5368):1455-7, 1998. 3. Groppe J, et al. Nature 420(6916):636-42, 2002. |
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