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| Catalog Code: | NB110-59941 |
| Product Name: | Dsh-3 Antibody |
| Product Description: | Rabbit Monoclonal anti-Dsh-3 (EP1991Y) |
| Clone: | EP1991Y |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Specificity: | A synthetic peptide corresponding to residues near the C-terminus of human Dsh-3 was used as an immungen. |
| Cross Reactivity: | This antibody is reactive against human, mouse and rat. |
| Packaging: | 0.1 ml |
| Uses: | This antibody works in WB, IHC, ICC, FC. The molecular weight in WB is 95 kDa. |
| Background: | The human DVL-3 gene encodes a predicted 716 amino acid protein which exhibits 98% amino acid identity with mouse Dsh-3 and 49% with Drosophila Dsh. Dsh-3 was mapped to 3q27. The expression of Dsh-3 mRNA was detected in 30 human cell lines and 2 primary cell cultures. Dsh-3 mRNA was detected in normal human breast tissues and tumors. Statistically, there was no difference in Dsh-3 mRNA level between normal breast tissues and tumors. In human colorectal samples, Dsh-3 was expressed equally in matched normal tissues, polyps and tumors. The data indicaes that Dsh-3 is widely expressed in human cells and may have a widespread role in signal transduction (1). Results indicate that the human dishevelled genes constitute a multigene family and that Dsh 3 proteins are highly conserved among metazoans. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | immunohistochemistry, Western Blot 1:500 1000, Immunocytochemistry, FC 1:30 |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Dishevelled-3, anti-DSH homolog 3 antibody |
| Package Size: | 0.1 ml |
| General References: | 1. Bui TD, et al. Biochem Biophys Res Commun 239(2): 510-6, 1997. 2. Semenov MV, et al. Genomics 42(2):302-10, 1997. |
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