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| Catalog Code: | NB110-59937 |
| Product Name: | Alpha-2 Catenin Antibody |
| Product Description: | Rabbit Monoclonal anti-Alpha-2 Catenin (EPR1795) |
| Clone: | EPR1795 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Specificity: | A synthetic peptide corresponding to residues in human a-2 Catenin was used as an immungen. |
| Cross Reactivity: | This antibody is reactive against human, mouse and rat. |
| Packaging: | 0.1 ml Rabbit ascites. |
| Uses: | This antibody works in WB, ICC, IP. The molecular weight in WB is 102kDa. |
| Background: | It has been shown that alpha N-catenin, a linker between cadherin adhesion receptors and the actin cytoskeleton, is essential for stabilizing dendritic spines in rodent hippocampal neurons in culture. Results suggest that alpha N-catenin is a key regulator for the stability of synaptic contacts (1). We show here that antibodies against alpha catenin also immunoprecipitate complexes that contain human N-cadherin, mouse P-cadherin, chicken A-CAM (adherens junction-specific CAM; also called N-cadherin) or Xenopus U-cadherin, demonstrating that alpha catenin is complexed with other cadherins(2). |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Application Summary: | immunoprecipitation 1:50, Western Blot 1:1000 - 2000, Immunocytochemistry 1:50 |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | Alpha-catenin-related protein, Alpha N-catenin |
| Package Size: | 0.1 ml |
| General References: | 1. Abe K, et al. Nat Neurosic 7(4): 357-63, 2004 2. Herrenknecht K, et al. Proc Natl Acad Sci 88(20): 9156-60, 1991 |
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