| CatalogCode: | NB110-59932 |
| ProductName: | ERCC1 Antibody |
| Product Description: | Mouse Monoclonal anti-ERCC1 (8F1) |
| Clone: | 8F1 |
| Clonality: | Monoclonal |
| Immunogen: | BALB/C mice were injected with full length recombinant human ERCC1 protein. |
| Specificity: | This antibody reacts with a 33-36 KDa protein known as ERCC1 (Excession Repair Cross Complementing) polypeptide. ERCC1 is required for nucleotide excision repair of damaged DNA and is homologous to RAD10. In mammalian cells, XPG cleaves 3' of the DNA lesion while ERCC1-XPF makes the 5' incision. This antibody cross reacts with rat. |
| CrossReactivity: | This antibody is reactive against human and rat. |
| Packaging: | 6 ml IgG purified Mouse ascites. |
| Uses: | This antibody works in IHC, IP, WB, IHC-P, IHC-Fr |
| Localization: | Nuclear |
| Control: | Tonsil |
| Background: | The mammalian ERCC1 (Excision Repair Cross Complementing) polypeptide is required for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which functions in repair and mitotic intrachromosomal recombination. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5'incision. Elevated levels of ERCC1 have also been reported in Cisplatin-resistant cells. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG2b |
| Host_Name: | Mouse |
| Buffer: | PBS with sodium azide |
| ListPrice: | 295 |
| AppSummary: | IHC, IP, WB, IHC-P, IHC-Fr |
| SpeciesSummary: | Hu, Rt |
| ALTnames: | anti-DNA excision repair protein ERCC 1 antibody, anti-DNA excision repair protein ERCC1 antibody, anti-ERCC 1 antibody, anti-Excision repair cross complementing 1 antibody, anti-Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1 antibody, anti-Excision repair protein antibody, anti-UV 20 antibody, anti-UV20 antibody |
| PackageSize: | 6 ml |
| GeneralRef: | i) Hayashi et al. Mutat Res 407: 269, 1996. ii) Miura et al. Exp Cell Res 226: 126, 1996. |
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