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| Catalog Code: | NB110-59931 |
| Product Name: | Tyrosinase Antibody |
| Product Description: | Mouse Monoclonal anti-Tyrosinase (T311) |
| Clone: | T311 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | BALB/C mice were injected with a recombinant tyrosinase protein. |
| Specificity: | This antibody is specific to a cluster of proteins between 70-80 kD known as tyrosinase. This antibody does not show any cross-reaction with MAGE-1 and tyrosinase-related protein-1, TRP-1/gp75. Staining of melanomas with this antibody showed tyrosinase in melanotic as well as amelanotic variants. |
| Cross Reactivity: | This antibody is reactive against human. |
| Packaging: | 6 ml Tissue culture supernatant Mouse ascites. |
| Uses: | This antibody works in IHC. |
| Localization: | Cytoplasmic |
| Background: | Tyrosinase is a copper containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. It is thought to catalyze the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
A mutant allele of TYR is a common cause of autosomal recessive ocular albinism, also known as tyrosinase negative oculocutaneous albinism. This is an autosomal recessive disorder characterized by absence of pigment in hair, skin and eyes. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG2a |
| Host Name: | Mouse |
| Buffer: | PBS, Tissue Culture Supernatant. pH 7.3; Protein carrier |
| Application Summary: | immunohistochemistry |
| Species Summary: | Hu, |
| Alternate Names: | anti-LB24 AB antibody, anti-Monophenol monooxygenase antibody, anti-OCA1A antibody, anti-OCAIA antibody, anti-Oculocutaneous albinism IA antibody, anti-SK29 AB antibody, anti-Tumor rejection antigen AB antibody, anti-TYR antibody, anti-tyrosinase (oculocutaneous albinism IA) antibody |
| Package Size: | 6 ml |
| Preservative: | Proprietary, not sodium azide or thimerosal |
| General References: | i) Chen et al. Proc Natl Acad Sci USA 92: 8125, 1995 |
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more information: | company product webpage |