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| Catalog Code: | NB110-59930 |
| Product Name: | MLH-1 Antibody |
| Product Description: | Mouse Monoclonal anti-MLH-1 (G168-15) |
| Clone: | G168-15 |
| Clonality: | Monoclonal |
| ListPrice: | 385 |
| Immunogen: | Full length recombinant MLH. |
| Specificity: | The G168-15 antibody recognizes the human and mouse MLH1 (80-85kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. This antibody cross reacts with human, hamster and rat |
| Cross Reactivity: | Thsi antibody is reactive against human, mouse, hamster and rat. |
| Packaging: | 6 ml protein A purified Mouse ascites. |
| Uses: | This antibody works in IHC-P, ICC/IF. |
| Localization: | Nuclear |
| Background: | MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPCC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Application Summary: | immunofluorescence, Immunocytochemistry, Immunohistochemistry-Paraffin |
| Species Summary: | Ha, Hu, Mu, Rt, |
| Alternate Names: | anti-COCA 2 antibody, anti-COCA2 antibody, anti-DNA mismatch repair protein Mlh1 antibody, anti-FCC 2 antibody, anti-FCC2 antibody, anti-hMLH 1 antibody, anti-hMLH1 antibody, anti-HNPCC 2 antibody, anti-HNPCC antibody, anti-HNPCC2 antibody, anti-MGC5172 antibody, anti-MLH 1 antibody, anti-MutL homolog 1 antibody, anti-MutL homolog 1 colon cancer nonpolyposis type 2 antibody, anti-MutL protein homolog 1 antibody |
| Package Size: | 6 ml |
| Preservative: | Sodium Azide |
| General References: | Machin et al. J Cutan Pathol 29 (7): 415, 2002 |
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more information: | company product webpage |
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