| CatalogCode: | NB110-59921 |
| ProductName: | Cytokeratin 5 Antibody |
| Product Description: | Mouse Monoclonal anti-Cytokeratin 5 (XM26) |
| Clone: | XM26 |
| Clonality: | Monoclonal |
| Immunogen: | BALB/C mice were injected with prokaryotic recombinant protein corresponding to 103 amino aced portion of C-terminal region of the human cytokeratin 5 molecule. |
| Specificity: | This antibody reacts with cytokeratin 5 intermediate filament protein. Basal cells of human epidermis express acidic cytokeratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kD protein, which is closely related to cytokeratin 6. Cytokeratin 5 and 6 are expressed in basal cell epithelioma, basal cells of prostate, urothelium, vagina, squamous cell carcinomas of skin, tongue, epiglottis and rectal-anal region. cytokeratin 5 can be useful in the distinction of mesotheliomas from most adenocarcinomas. |
| CrossReactivity: | This antibody is reactive against human. |
| Packaging: | 6 ml Tissue culture supernatant Mouse ascites. |
| Uses: | This antibody works in IHC. |
| Localization: | Cytoplasmic |
| Control: | Skin |
| Background: | Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinising tissue (ie., skin) and non keratinising cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40 to 70 kDa and isoelectric points of 5 to 8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Defects in KRT5 are a cause of epidermolysis bullosa simplex. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG1, kappa |
| Host_Name: | Mouse |
| Buffer: | Tissue culture supernatant |
| ListPrice: | 295 |
| AppSummary: | IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-58 kDa cytokeratin antibody, anti-CK 5 antibody, anti-CK5 antibody, anti-Cytokeratin5 antibody, anti-DDD antibody, anti-EBS 2 antibody, anti-EBS2 antibody, anti-K5 antibody, anti-Keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types) antibody, anti-Keratin 5 antibody, anti-Keratin Type II Cytoskeletal 5 antibody, anti-Keratin5 antibody, anti-KRT 5 antibody, anti-KRT 5A antibody, anti-KRT5 antibody, anti-KRT5A antibody |
| PackageSize: | 6 ml |
| GeneralRef: | i) Irvine et al. J Invest Dermatol 108: 809, 1997. ii) Whittock et al. Biochem Biophys Res Commun 274: 149, 2000. |
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