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| Catalog Code: | NB110-59920 |
| Product Name: | Cytokeratin 14 Antibody |
| Product Description: | Mouse Monoclonal anti-Cytokeratin 14 (LL002) |
| Clone: | LL002 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | A synthetic peptide of 15 amino acid residues from the C-terminus of human keratin 14. |
| Specificity: | This antibody is specific to 50 cytokeratin protein designated cytokeratin 14. Cytokeratin 14 belongs to the type A (acidic) subfamily of low MW cytokeratins and exists in combinations with cytokeratin 15. This antibody can be useful to distinguish stratified epithelial cells from simple epithelial cells. |
| Cross Reactivity: | This antibody is reactive against human. |
| Packaging: | 6 ml Tissue culture supernatant Mouse ascites. |
| Uses: | This antibody works in IHC, WB. |
| Localization: | Cytoplasmic |
| Background: | Keratin 14 is a member of the keratin family, the most diverse group of intermediate filaments. It is usually found as a heterotetramer with two molecules of keratin 5, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. Keratin 14 has been studied as a prognostic marker in breast cancer. This antibody labels the basal layer of stratifying squamous and non-squamous epithelia. The staining pattern iscytoplasmic. It recognizes basal cell carcinomas and squamous cell carcinomas. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG3 |
| Host Name: | Mouse |
| Buffer: | 20 mM tris-borate, 150 mM sodium chloride,0.1% sodium azide |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, |
| Alternate Names: | anti-CK 14 antibody, anti-ck14 antibody, anti-Cytokeratin 14 antibody, anti-Cytokeratin14 antibody, anti-Dowling Meara antibody, anti-ebs3 antibody, anti-ebs4 antibody, anti-Epidermolysis bullosa simplex antibody, anti-k14 antibody, anti-Keratin 14 antibody, anti-Keratin type I cytoskeletal 14 antibody, anti-Keratin14 antibody, anti-Koebner antibody, anti-Krt 14 antibody, # krt14 antibody |
| Package Size: | 6 ml |
| General References: | i) Lane et al. Can Biol 1: 165, 1990. ii) Moll et al. Cell 31: 11, 1982. iii) Purkis et al. J Cell Sci 97: 39, 1990. iv) Westzels et al. Am J Pathol 134: 571, 1989. |
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