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| Catalog Code: | NB110-59916 |
| Product Name: | p53 Antibody |
| Product Description: | Rabbit Polyclonal anti-p53 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant full-length wild type p53 protein. |
| Specificity: | This antibody reacts with a 53 kD protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types. It is involved in regulating cell growth, replication and apoptosis. It binds to mdm2, SV40 T antigen and human Papilloma virus E6 protein. Mutation involving p53 is found in wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung and melanoma. This antibody crossreacts with mouse and rat. |
| Cross Reactivity: | This antibody is reactive against maouse and rat. |
| Packaging: | 6 ml IgG purified Rabbit antisera. |
| Uses: | This antibody works in IHC. |
| Localization: | Nuclear |
| Background: | p53 plays a major role in the cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair, or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNAPK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is altered in human tumors and has been reported to influence the growth suppressor function, DNA binding and transcriptional activation of p53. p53 is phosphorylated at Ser6 and Ser9 by ck1d and ck1e both in vitro and in vivo. Phosphorylation of p53 at Ser46 is important in regulating the ability of p53 to induce apoptosis. In vivo phosphorylation of p53 at Ser33 by cdk7/cyclin H and in response to UV irradiation has been observed. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS with sodium azide |
| Application Summary: | immunohistochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-Antigen NY-CO-13 antibody, anti-Cellular tumor antigen p53 antibody, anti-Cys 51 Stop antibody, anti-HGNC11998 antibody, anti-LFS1 antibody, anti-p53 Cellular Tumor Antigen antibody, anti-p53 Tumor Suppressor antibody, anti-Phosphoprotein p53 antibody, anti-TP53 antibody, anti-Transformation related protein 53 antibody, anti-TRP53 antibody, anti-Tumour Protein p53 antibody |
| Package Size: | 6 ml |
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