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| Catalog Code: | NB110-59729SS |
| Product Name: | LOX Antibody |
| Product Description: | Rabbit Polyclonal anti-LOX, Sample Size |
| Clonality: | Polyclonal |
| ListPrice: | 100 |
| Gene ID: | 4015 |
| Immunogen: | Two synthetic peptides (a.a. 181-196 and 293-309) of the rat LOX protein. |
| Cross Reactivity: | This antibody reacts with rat and mouse protein. It is expected to react with human protein but it has not been tested. Other species have not been tested. |
| Packaging: | 0.025 ml Whole Rabbit antisera. |
| Localization: | Cytosolic and nuclear |
| Background: | Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host Name: | Rabbit |
| Application Summary: | Western Blot |
| Species Summary: | Mu, Rt, , |
| Alternate Names: | anti-LOX antibody; anti-lysyl oxidase antibody; anti-MGC105112 antibody; anti-protein-lysine 6-oxidase antibody |
| Package Size: | 0.025 ml |
| Preservative: | 0.1% sodium azide |
| Homology: | The immunogen is highly conserved with human, rat, mouse, and chick. |
| Product References: | 1. Jeay, S. et al. Lysyl Oxidase Inhibits Ras-Mediated Transformation by Preventing Activation of NF-kB. Mol. and Cell Biol. 23(7): 2251-2263 (2003) [Western blot] |
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