| request information: |
|
| Catalog Code: | NB110-58851L |
| Product Name: | NOX4 Antibody |
| Product Description: | Rabbit Polyclonal anti-NOX4 , conjugated to HiLyte Fluor 488 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 50507 |
| Immunogen: | A synthetic peptide made to a C-terminal region (within residues 500-578) of the human NOX4 protein sequence. [Swiss-Prot# Q9NPH5] |
| Cross Reactivity: | This antibody reacts with human protein. Other species have not been tested. |
| Packaging: | 0.1 ml peptide affinity purified Rabbit antisera. |
| Uses: | By Western Blot, this antibody recognizes bands at ~67kDa and ~31.8kDa, representing isoforms 1 and 4, respectively. |
| Localization: | Endoplasmic reticulum, endoplasmic reticulum membrane, multi-pass membrane protein, cell membrane, nucleus (probable). |
| Background: | Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | peptide affinity purified |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate, pH 7-8 |
| Application Summary: | immunohistochemistry 10-20 ug/ml, Western Blot 2 ug/ml |
| Species Summary: | Hu |
| Alternate Names: | anti-NADPH Oxidase 4 antibody; anti-Renal NADPH Oxidase antibody; anti-RENOX antibody; anti-Kidney superoxide-producing NADPH oxidase antibody; anti-KOX-1 antibody; anti-EC 1.6.3 antibody |
| Package Size: | 0.1 ml |
| Preservative: | no preservative |
| Homology: | 100% human, mouse, rat, and monkey proteins. |
| Conjugate: | HiLyte Fluor 488 |
| Notes Main: | Hilyte fluor dyes (patent pending) manufactured by Anaspec,Inc. |
| Product References: | 1. Maranchie and Zhan. Nox4 Is Critical for Hypoxia-Inducible Factor 2-A Transcriptional Activity in von Hippel-Lindau-Deficient Renal Cell Carcinoma. Cancer Research. 65(20): 9190-3 (2005) |
order or
more information: | company product webpage |