| Catalog Code: | NB110-5846 |
| Product Type: | Primary Antibody |
| Product Name: | EGF Receptor Antibody |
| List Price: | 325 |
| Clonality: | Monoclonal |
| Gene ID: | 1956 |
| Host: | Mouse |
| Clone: | 528 |
| Isotype: | IgG2a |
| Product Description: | Mouse Monoclonal anti-EGF Receptor (528) |
| Cross Reactivity: | Cross-reacts with Human and Dog. Does not cross-react with Rat or Mouse. Not yet tested in other species. |
| Species Summary: | Ca, Hu, Mu(-), Rt(-) |
| Background: | EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), emphiregulin, betacellulin and epireguli |
| Immunogen: | Purified EGFR from A431 cells. |
| Epitope: | Extracellular domain. |
| Localization: | Cell Membrane and Secreted |
| Purity: | protein A purified |
| Buffer: | 10mM PBS, pH7.4, 0.2%BSA |
| Packaging: | 0.5 ml protein A purified Mouse ascites. |
| Package Size: | 0.5 ml |
| Concentration: | 0.2 mg/ml |
| Uses: | This antibody blocks EGF / TGF alpha induced activation of EGFR (Kawamoto T, et. al.; Sato JD, et. al.). It also blocks tumor growth invivo. It has no effect on tyrosine kinase activity ofthe receptor. (Order Ab without azide; Ab at 0.5ug/ml, cells induc |
| Application Summary: | FACS, IP |
| General References: | Wikstrand CJ et al. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res 55:3140-8 (1995). <PUBMED:7606735> Hartigh JC et al. Cholesterol and phosphoinositides increase |
| Notes Main: | Also available without BSA and azide at 1mg/ml for $325. Catalog code is NB110-5846AF. |
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