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| Catalog Code: | NB110-58360SS |
| Product Name: | Fe65 Antibody |
| Product Description: | Rabbit Polyclonal anti-Fe65, Sample Size |
| Clonality: | Polyclonal |
| ListPrice: | 100 |
| Gene ID: | 322 |
| Immunogen: | Recombinant rat protein expressed in bacteria. |
| Cross Reactivity: | This antibody reacts with the rat, human, and mouse proteins. |
| Packaging: | 0.025 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful in Western Blot and immunoprecipitation. For western blot, a band is seen at ~100 kDa ((calculated MW of 77.2kDa according to NP_001155.1 and 77.0kDa according to NP_663722.1). The observed molecular weight corresponds to earlier findings in literature (Zambrano et al, J Biol Chem. 1998 Aug 7;273(32):20128-33.; PMID: 9685356).) |
| Background: | FE65 is a signling adaptor of APP protein. The FE65/APP complex was shown to translocate into the cell nucleus and regulate gene expression. Genetic studies in mice validated FE65-APP interaction and molecular studies provided evidence on the role of the complex in abnormal signaling dtected in brains of Alzheimer Disease patients. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Host Name: | Rabbit |
| Buffer: | PBS, 15% glycerol |
| Application Summary: | immunoprecipitation , Western Blot 1:1000 |
| Species Summary: | Hu, Rt, Mu, |
| Alternate Names: | anti-Amyloid beta A4 precursor protein-binding family B member 1 antibody, anti-Fe65 protein antibody, anti-APBB1 antibody, anti-FE65 antibody, anti-RIR antibody, anti-MGC:9072 antibody |
| Package Size: | 0.025 ml |
| Preservative: | 0.02% sodium azide |
| Homology: | Rat |
| General References: | 1. Zambrano, N., et al. Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of FE65 with Wild-type and Mutant Alzheimer's beta-amyloid Precursor Proteins. JBC. 272:6399-405 (1997). [Western Blot, Immunoprecipitation] 2. Cao, X., and Sudhof, TC. A Transcriptionally active complex of APP with FE65 and Histone Acetylase TIP60. Science. 293:115-120 (2001). 3. Guenette, S., et al. Essential Roles for the FE65 Amyloid Precursor Protein-interaction Proteins in Brain Development. EMBO. 25:420-431 (2006). [Immunohisto/cytochemistry] 4. Muller, T., et al. Modulation of Gene Expression and Cytoskeletal Dynamics by the APP Intracellular Domain. MBC. Ahead of publication. |
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