| CatalogCode: | NB110-58358SS |
| ProductName: | YAP Antibody |
| Product Description: | Rabbit Polyclonal anti-YAP |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant YAP protein expressed in bacteria. |
| CrossReactivity: | This antibody reacts with the human protein. |
| Packaging: | 0.025 ml Affinity purified Rabbit antisera. |
| Uses: | This 65 kDa antibody is useful in Western Blot against transfected HEK 293 lysates. |
| Localization: | Nuclear |
| Control: | Brain and kidney lysates, and HEK 293 cell lysate |
| Background: | YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. As one of several genes of 1q22 amplicon, YAP was recently implicated in liver and breast cancer. Overexpression of YAP gene in MCF10A mammary cell line induces oncogenic transformation. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | PBS, 15% glycerol |
| ListPrice: | 100 |
| AppSummary: | IP, WB, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-YAP65 antibody, anti-Yes associated protein antibody, anti-YAP1 antibody, anti-YAP2 antibody |
| PackageSize: | 0.025 ml |
| GeneralRef: | 1. Sudol, M., et al. Characterization of the Mammilian YAP Gene and Its Role in Defining a Novel Protein Module, the WW Domain. JBC. 14733-14741 (1995). 2. Komuro, A., et al. WW Domain-containing Protein YAP Associates with WrbB-4 and Acts as a Co-transcriptional Activator for the Carboxyterminal Fragment of ErB4 that Translocates to the Nucleus. JBC. 33334-33341 (2003). 3. Zender, L., et al. Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach. Cell. 125:1230-3 (2006). [Western blot, Immunohistochemistry] 4. Dong, G., et al. Molecular Profiling of Transformed and Metastatic Murine Squamous Carcinoma Cells by Differential Display and cDNA Microarray Reveals Altered Expression of Multiple Genes Related to Growth, Apoptosis, Angiogenesis, and the NF-kappaB Signal Pathway. Cancer Res. 61:4797-808 (2001). 5. Overholtzer, M., et al. Transforming Properties of Yap, a Candidate Oncogene of the Chromosome 11q22 Amplicon. PNAS. 103:12405-10 (2006). |
| Gene_Id: | 10413 |
| Omim_ID: | NB110-58358 |
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